Temporal and Clonal Progression in a Pediatric Ependymoma Patient Through Multiple Treatments
نویسندگان
چکیده
Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO, United States McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, United States Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States Institute for Genomic Medicine, Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, United States
منابع مشابه
A novel case of quartet tumor: meningioma, angiomyolipoma, ependymoma and sarcoma: report of a case and review of the literature
Multiple primary tumors in a single patient are relatively rare when four or more distinct lesions are considered. Herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade soft tissue sarcoma. There was no family history and hereditary syndrome. The genetic analysis was completely normal. To best of our knowledge, t...
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PURPOSE The outcome of recurrent ependymoma in children is dismal. Reirradiation has been proposed as an effective modality for ependymoma at relapse. However, the toxicity and outcome benefits of this approach have not been well established. METHODS AND MATERIALS We conducted a retrospective population-based study of all patients with recurrent ependymoma treated between 1986 and 2010 in our...
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Ependymoma constitute 5 % to 7 % of all primary CNS neoplasm. But their prevalence relative to other tumor type varies with patient age and presenting location. Ependymoma constitute approximately 1O % of intracranial neoplasm in pediatric population and up to 30 % of those encountered in children under 3 years of age. In spinal column, ependymoma constitute 60% of glial neoplasm, and opposed...
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Brain tumors are the leading cause of cancer death in children, with ependymoma being the third most common and posing a significant clinical burden. Its mechanism of pathogenesis, reliable prognostic indicators, and effective treatments other than surgical resection have all remained elusive. Until recently, ependymoma research was hindered by the small number of tumors available for study, lo...
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